amitriptyline drug interaction::Finally, we evaluated in vivo interaction between oxycodone and amitriptyline in mice amitriptyline drug interaction

amitriptyline drug interaction::Finally, we evaluated in vivo interaction between oxycodone and amitriptyline in mice.
Antinociceptive effects of oxycodone were increased by coadministration of amitriptyline.
The oxycodone concentrations in plasma and brain were not changed by coadministration of amitriptyline.
Overall, the results suggest that several adjuvant analgesics may interact with the bbb transport of oxycodone at relatively high concentrations.
However, it is unlikely that there would be any significant interaction at therapeutically or pharmacologically relevant concentrations.